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Dopaminergic signaling in the prefrontal cortex can be altered by D2-like dopamine receptor inhibition in the nucleus accumbens.
The prefrontal cortex (PFC) is the key node of the brain network governing cognitive functions, including complex ones such as decision-making. Dopaminergic modulation of PFC function may be achieved by action of dopamine D1 and D2 receptors in the PFC and adjacent sub-cortical nuclei. The present study assessed the contribution of D2 receptors in the PFC to actions of dopamine (DA) in the nucleus accumbens (NAc) in rats performing a decision-making task. In the decision-making task, rats must decide between two alternative strategies to obtain the same reward: strategy A promotes food intake and strategy B prevents food intake. Animals alternated between these two strategies following a probabilistic schedule: animals always selected the "feed" option if the probability of obtaining the reward was low, while they never selected this strategy if the probability of obtaining the reward was high. D2 receptor blockade in the PFC (or prefrontal cortex) increased subsequent food intake under certain conditions. In contrast, it decreased food intake under other conditions. These effects were mimicked by prior DA depletion in the NAc core. Preference behavior was not modified. Systemic administration of a D2 dopamine receptor antagonist into the PFC produced no significant effects on preference behavior or food intake. These results show a differential contribution of DA D1 and D2 receptors in the PFC to DA signaling in the NAc.1. Field of the Invention
The present invention relates to a storage device in a computer system which is capable of storing a plurality of first or second storage areas therein, comprising an access time equalizer circuit which is operative to adjust the access time to a first or second storage area, a selector which is operative to selectively allow or prevent access to the first or second storage area, and a control circuit which is operative to control the access time equalizer circuit.
2. Description of the Prior Art
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