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The volume of the thyroid gland and its central compartment was measured in 108 healthy people of both sexes aged 14 to 60 years, with the use of the dual counter technique. This technique (Scilight) is based on the principle of electrical conductance of a narrow-gap electrolyte solution. The mean volume of the thyroid gland was found to be approximately 41.8 +/- 9.4 cc. The correlation coefficient for this relationship was 0.99 (p less than 0.01). The volumes of the thyroid gland and its central compartment were significantly higher in women than in men. However, the difference was not statistically significant, and the mean volumes of the central compartment in the two sexes were almost identical. The mean volume of the thyroid gland in younger people was found to be higher, and it increased with age. The volume of the central compartment did not increase significantly with age.Functional characterization of the human serine/threonine protein kinase, ERK kinase 1 (MEKK1).
The serine/threonine protein kinase, MEK kinase 1 (MEKK1), is a member of the mitogen-activated protein (MAP) kinase superfamily and is the specific kinase responsible for the activation of ERK MAP kinase. We have characterized the substrate specificity of MEKK1 and describe the functional consequences of MEKK1 overexpression in HEK 293 cells.
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